Researchers at Lawson Health Research Institute and Western University are using a new brain imaging technique to detect preserved consciousness in the intensive care unit (ICU) at London Health Sciences Centre (LHSC) in patients that appear to be in a coma following a severe brain injury.

In a groundbreaking discovery published in The Proceedings of the National Academy of Sciences (PNAS), researchers used functional near infrared spectroscopy (fNIRS), a portable brain imaging technique, to examine whether unresponsive patients in the ICU had preserved consciousness by recording brain activity at their bedside. 

For the study, the research team led by Dr. Karnig Kazazian, Dr. Androu Abdalmalak, and Dr. Derek Debicki used fNIRS to determine if patients can feel pain, hear their surroundings, and perhaps most crucially, retain preserved conscious awareness. They first tested this technique on more than 100 healthy individuals before using fNIRS to identify a patient in the intensive care unit who, despite being unresponsive, was able to demonstrate appropriate brain responses to the instruction “imagine playing a game of tennis,” which showed that they were aware. 

“These findings could fundamentally change the way patients are cared for,” said Dr. Kazazian, Research Associate at Lawson Health Research Institute and LHSC, and Associate Scientist and medical student at Western University’s Schulich School of Medicine & Dentistry. “Deploying a simple tool like fNIRS at the bedside has the potential to provide clinicians information about preserved brain function that standard clinical tools are not
capable of doing”. 

This discovery builds on more than 20 years of research from renowned Western neuroscientist Dr.Adrian Owen, who first discovered that some unresponsive patients are entirely aware based on results from brain recordings. It also expands on recent advances made the research team using fMRI and EEG in patients with severe brain injury.

“Families of patients with severe brain injuries want to know whether their loved ones will be able to recover from their injuries,” said Dr. Debicki, a Neurologist at LHSC, Assistant Professor of Neurology at Schulich Medicine & Dentistry and Scientist at Lawson. “fNIRS is an exciting new tool that we can use at the bedside in the ICU to improve the way we answer this very important, complex question.”

Beyond making predictions about outcomes, fNIRS may provide a unique opportunity to interact with patients who are aware but unable to be physically interactive. 

“The next steps are incredibly exciting, as expanding the testing to a larger group of patients will enable us to explore the potential of using fNIRS to communicate with ICU patients, potentially unlocking groundbreaking advancements in patient care,” said Dr. Abdalmalak, a former Research Associate in the Owen Lab at Western University’s Schulich School of Medicine & Dentistry.