HomeMedical SpecialtiesGeriatrics and AgingBlood test can predict Alzheimer’s disease

Blood test can predict Alzheimer’s disease

Published on

A blood test that can predict with 90 per cent accuracy if a healthy person will develop mild cognitive impairment (MCI) or Alzheimer’s disease within three years has been discovered and validated by researchers at Georgetown University and six other institutions.

The study team explains in the April issue of Nature Medicine  how they discovered and then validated a set of 10 lipid biomarkers in the blood that predict both conditions.

The discovery heralds the possible development of earlier treatment options for Alzheimer’s, when therapy could be more effective at slowing or even preventing onset of the disease.

“Our novel blood test offers the potential to identify people at risk for progressive cognitive decline and can change how patients, their families and treating physicians plan for and manage the disorder,” says the study’s corresponding author, Dr. Howard J. Federoff, executive vice president of health sciences at Georgetown University Medical Center.

There is currently no cure or effective treatment for Alzheimer’s disease, which, according to the World Health Organization, is expected to double every 20 years worldwide – from 35.6 million individuals in 2010 to 115.4 million by 2050.

Federoff, also a professor of neurology, explains there have been many efforts to develop drugs to slow or reverse the progression of Alzheimer’s disease, but all of them have failed. He says one reason may be the drugs were evaluated too late in the disease process.

“The preclinical state of the disease offers a window of opportunity for timely disease-modifying intervention, and biomarkers defining this asymptomatic period are critical for successful development and application of these therapeutics,” says Federoff.

‘Major Step Forward’

“The lipid panel was able to distinguish with 90 percent accuracy these two distinct groups – cognitively normal participants who would progress to MCI or AD within two to three years, and those who would remain normal in the near future,” says Federoff, who also serves as executive dean of the School of Medicine.

Researchers say the panel reveals changes in the breakdown of neural cell membranes resulting in 10 identifiable lipids, or metabolites, circulating in the blood. In particular, two of the 10 metabolites have strong links to the neuropathology of Alzheimer’s.

“We consider our results a major step toward the commercialization of a preclinical disease biomarker test that could be useful for large-scale screening to identify at-risk individuals,” Federoff concludes. “We’re intending to design a clinical trial where we’ll use this panel to identify people at high risk for Alzheimer’s to test a therapeutic agent that might delay or prevent the emergence of the disease.”

Latest articles

The Canadian Consensus Statement on the management of venous leg ulcers

This Consensus Statement was developed with the objective of creating a concise document that...

A pathway to independence for patients with rare disease

Nearly 20 years ago, Audrey Gouskos came through the St. Michael’s Hospital Emergency Department...

Robotic-assisted rehabilitation now available in Fraser Health

Stroke patient Leanne Mork is learning to walk again with the assistance of a...

Helping Canada Design Health Care Facilities for Future Needs

Health care facilities (HCFs) play an important role in communities, providing a safe, secure,...

More like this

Robotic-assisted rehabilitation now available in Fraser Health

Stroke patient Leanne Mork is learning to walk again with the assistance of a...

AI innovation unlocks non-surgical way to detect brain cancer spread

In new study, MRI combined with machine learning reveals presence of cancer cells with...

World first: Delivering chemotherapy to paediatric brain tumours using MRI-guided focused ultrasound

Researchers and physicians at Sunnybrook Health Sciences Centre and The Hospital for Sick Children...

Move more, age well: prescribing physical activity for older adults as a recipe for healthy aging

Can physical activity extend the lifespans of older adults? A review article published in CMAJ (Canadian...

Antipsychotic use has been rising in long-term care homes, but we can do something about it – we’ve done it before

As health care providers working in long-term care (LTC), we’ve seen firsthand how antipsychotic...

Revving up older patients’ metabolism could be the key to healing from severe burns

Older patients suffering a severe burn are at a much higher risk of dying...